Carlos Hyde and Darwin Thompson were enough cause for concern to Damien Williams' workload, and switching Hyde for LeSean McCoy didn't ease those concerns any.
Marquez Valdes-Scantling was headed for a starting role anyway, but his route to a three-down role became even clearer with the ankle injury suffered by teammate Equanimeous St. Brown.
There's an understandable lack of enthusiasm around the Jacksonville passing game, but there's a surprisingly deep group of receivers there with Marqise Lee (knee) back.
Recent media coverage of the 49ers has implied a souring reception of Dante Pettis, but it will present an opportunity for profit if his price drops.
Despite a wide range of speculation regarding the Chiefs RBs behind Damien Williams (hamstring), Carlos Hyde was listed as the top backup on the first Kansas City depth chart.
Kenyan Drake was the presumed starter in Miami, but the big and fast Kalen Ballage opened Dolphins training camp as the starting running back.
Devontae Booker appeared locked in as the RB3 in Denver, but a pair of recent additions have shown well in practices. There are a couple unlikely Bronco wideout prospects pushing for playing time, too.
If Melvin Gordon holds out, Austin Ekeler and Justin Jackson both appear qualified for bigger workloads. Also looking at the Broncos RBs as well as wideouts in Tampa and Baltimore.
D.J. Moore is one of the most hyped wide receivers heading into 2019, but there's a good chance that Curtis Samuel posts the bigger numbers this year.
Rashaad Penny's rookie year didn't go well at all, but now that he's reportedly in improved shape he could issue a serious challenge to incumbent Chris Carson.
Zach Zenner fell off the radar for a couple years, but the former South Dakota State standout has always played convincingly when given the opportunity.
Spencer Ware was set to take over the Kansas City backfield following the release of Kareem Hunt, but Ware's injuries opened the door for Damien Williams.
Devin Funchess is still probably a good prospect at wide receiver, but Curtis Samuel and D.J. Moore threaten to make him irrelevant all the same.
Gus Edwards was a late-season lifeline for those who added him a few weeks ago, but the return of Kenneth Dixon from IR could complicate the formula for Edwards.
Corey Clement still lurks in the background after playing well off the bench Sunday, but Adams has all the momentum after a 22-carry effort.
Demaryius Thomas was expected to see a substantial workload after Houston acquired him for a fourth-round pick, but rookie Keke Coutee appears Houston's WR2 for now.
Eric Ebron put forth an improbable but dominant showing against the Jaguars on Sunday as Indianapolis' third TE. Is this enough to earn him a promotion?
Ryan Fitzpatrick was supposed to be good for DeSean Jackson and bad for Adam Humphries, but Humphries had the big game Sunday. Expect that to be a one-time deal.
There was ambiguity about how the Colts would handle their tight end rotation after Eric Ebron emerged while Jack Doyle sat with a hip injury, but Sunday's game against Oakland cleared everything up.
After two strong seasons to open his NFL career, Amari Cooper infuriated his fantasy owners with inconsistency the last two years. Will we get the Good Coop or Bad Coop in Dallas?
Tevin Coleman might find success as a lead runner in the NFL eventually, but in the past month he's consistently lost ground to rookie fourth-round pick Ito Smith.
With Jay Ajayi suffering a season-ending ACL tear, the surging Wendell Smallwood will compete with a recovering Corey Clement (quad) for valuable snaps in a high-scoring offense.
Tarik Cohen might have Jordan Howard owners tilting after the speedy back led the Bears assault from scrimmage against Tampa, but a rising tide should carry them both.
Baker Mayfield might be a rookie, but potential fantasy owners need not worry about his job security. This competition is over.
Robby Anderson was the presumed WR1 with the Jets since last year's emergence, but Quincy Enunwa never said he could have his spot.
Joe Mixon's big game was one of the top stories from Sunday, but it took an improbable disappearance of Gio Bernard to clear the way.
The Broncos thinned their running back depth chart by cutting DeAngelo Henderson on Saturday, then named Royce Freeman starter on Monday.
Marqise Lee's season-ending injury is a substantial loss for Jacksonville, but it clears an obvious opening for Donte Moncrief.
Alfred Morris seemed done for, but he merits close monitoring in upcoming days as the 49ers sort through their undersized and beat-up backfield.
LeGarrette Blount and rookie second-round pick Kerryon Johnson are fighting for carries in Detroit, but the rookie is closing in.