The Dolphins are looking to bring a shootout to the Bills, but Stefon Diggs is prepared to shoot back against Miami's questionable pass defense.
Drake London is due for a bounce-back after no catches in Week 1, but Jaire Alexander could deny it anyway.
Tyreek Hill and the Dolphins could be in line for another high-scoring game this week against the Bears.
To better protect Joe Burrow, the defending AFC champs fortified the O-line this offseason. Another Super Bowl bid is possible, but there are several contenders to reach the big game in a strong conference.
O-line will be at the top of the offseason shopping list for both Pittsburgh and Cincinnati, potentially helping Najee Harris and Joe Mixon reach new heights in 2022.
Odell Beckham might have some rust to shake off, but his matchup with the Vikings is perfect for a breakout.
The Bucs defense is no joke, but New England's Jakobi Meyers should push for double-digit targets against a banged-up secondary Sunday night.
The Vikings defense is begging to get burned deep Sunday, both by Tyler Lockett and DK Metcalf.
It could be a big day for Keenan Allen if Dallas matches up Trevon Diggs on Mike Williams.
The Colts could have a problem with DK Metcalf, especially if CB1 Xavier Rhodes (calf) can't play.