A win Thursday over Rapid Wien would see Inter Milan through to the round of 16, and the bookmakers are expecting Lautaro Martinez to make an impact.
Arsenal are the biggest favorite on Thursday's early eight-game slate, and no player has higher anytime goal scorer odds than Pierre-Emerick Aubameyang.
Olivier Giroud has scored in three straight league games, and a matchup against Swansea City on Saturday should give him a great opportunity to extend his streak.
Mesut Ozil is expected to return from an illness, and he has an excellent matchup against Swansea to produce lots of fantasy points.
Diego Costa looks ripe for fantasy points Saturday against Hull City, but is he the top play from Chelsea? Alex Spalding breaks down his top plays.
Paying up for players like Sergio Aguero puts extra importance on finding value in the lower ends of the salary scale. Adam Zdroik breaks down the best cheap options for the Premier League's official game.
After Cristiano Ronaldo went off for four goals and an assist Tuesday against Malmo, will Lionel Messi turn around and match him Wednesday?