Brandon Aiyuk's acceleration and ball-tracking skills could spell trouble for Kansas City's middling safeties, but first the Niners need to keep DL Chris Jones off of Brock Purdy.
Everyone agrees that Lamar Jackson needs to be blitzed, but just how much pressure should the Chiefs bring this Sunday?
The Chiefs' passing game has mostly been disappointing this year, but Rashee Rice and Travis Kelce both played well last week and now face a banged-up Buffalo secondary in the divisional round.
Trevor Lawrence finally suffered an injury he can't play through, with the Jaguars officially ruling him out for Week 17.
James Cook struggled against the Chargers on Saturday, but he dominated Buffalo's backfield snaps and touches to an extent previously unseen this season.
Mike Barner breaks down NFL Betting Picks Thursday Night Football, Week 12: Seattle Seahawks vs. San Francisco 49ers
Travis Etienne and the Jaguars will be looking to get right in Week 11, and Joe Bartel expects them to wind up on the right side of a matchup with the Titans.
Adam Warner takes you through this week's selections in the Circa Sports Million contest and tells you who else he is taking in addition to Taysom Hill and the Saints.
Tyler Boyd and Trenton Irwin could be busy for the Bengals this weekend with Tee Higgins ruled out and Ja'Marr Chase listed as questionable.
Jerry Donabedian foresees a bounce-back game for Geno Smith and DK Metcalf against a Washington defense that traded its two best pass rushers last week.
Jim Coventry reacts to the Week 8 action, including epic performances from Will Levis and DeAndre Hopkins.
The Seahawks' injury report was loaded throughout the week, but Friday brought good news for anyone counting on Kenneth Walker or Tyler Lockett this Sunday.
Kirk Cousins and the Vikings are on a roll, and RotoWire's Joe Bartel is banking on them maintaining the momentum when they head to Lambeau Field in Week 8.